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  • Title: Comparison of central effects of noradrenaline and dopamine injected into the lateral brain ventricle in rats.
    Author: Zebrowska-Lupina I, Malec D, Kleinrok Z.
    Journal: Acta Physiol Pol; 1975; 26(3):261-74. PubMed ID: 1242288.
    Abstract:
    Noradrenaline and dopamine injected into the lateral brain ventricle exerted a significant effect on the behavior of rats. Both amines caused a slight rise in the basic locomotor activity which was significantly increased in the animals with inhibited monoamine oxidase activity. Besides that, they suppressed the behavior of rats in the open-field test, inhibited the conditioned avoidance response, decreased body temperature and increased amphetamine-induced motor hyperactivity. Noradrenaline, in contrast to dopamine, changed the intensity of amphetamine-induced stereotypy and prolonged the action of hypnotics. The central action of both catecholamines (in higher doses especially) seemed to have a biphasic course: in the first phase after administration depression was observed which was more pronounced after noradrenaline administration, in the second phase a stimulating effect b
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