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  • Title: Long-term follow-up of cellular proliferation as a predictive index for the relapse of nasal polyposis.
    Author: Bruno E, Mohamed EI, Alessandrini M, Russo S, Schiaroli S, De Lorenzo A, Di Girolamo A.
    Journal: Am J Rhinol; 2002; 16(5):237-41. PubMed ID: 12422966.
    Abstract:
    BACKGROUND: The objective of this study was to identify a reproducible clinical parameter for predicting relapses of nasal polyposis after surgery. METHODS: Ninety-three patients who had undergone ethmoidectomy of bilateral nasal polyps were followed for 3 years. Nasal polyps were obtained from all patients, and cellular suspensions were analyzed individually using flow cytometry. Based on the percentage of cells in the S phase, we identified three groups of patients (high, medium, and low percentages). RESULTS: A relapse of nasal polyposis was observed in 15.00, 70.00, and 100.00% of patients from the low-, medium-, and high-percentage groups, respectively. Patients suffering relapses had a high percentage of cells in the S phase. CONCLUSIONS: We identified two cutoff values for the percentage of cells in the S phase; above the first cutoff, some of the patients suffered relapses; above the second cut-off, all patients suffered relapses.
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