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  • Title: The Synthesis of L-aminosugar and the studies of L-pyranoses on the ring III of pyranmycins.
    Author: Wang J, Li J, Tuttle D, Takemoto JY, Chang CW.
    Journal: Org Lett; 2002 Nov 14; 4(23):3997-4000. PubMed ID: 12423070.
    Abstract:
    The synthesis of a novel class of aminoglycoside, pyranmycin, and a convenient method for the preparation of 6-amino-L-idopyranosides were reported. One of the members in the reported pyranmycin families, TC010, has prominent activity against Escherichia coli, Staphylococcus aureus, and Bacillus megaterium. We also discovered that the (4)C(1) chair conformation on ring III of pyranmycin is essential for the antibacterial activity. [reaction: see text]
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