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  • Title: Pulmonary embolism with factor XI deficiency.
    Author: Brodsky JB, Burgess GE.
    Journal: JAMA; 1975 Dec 15; 234(11):1156-7. PubMed ID: 1242430.
    Abstract:
    A patient with factor XI deficiency had pulmonary embolism, although his factor XI assay was less than 1% of normal and his postoperative course was complicated by prolonged bleeding. Programs designed to prevent postoperative venous thrombosis should be carried out in factor XI-deficient patients, since the deficient state offers no protection from a pulmonary embolus. All surgical patients who are to receive low-dose heparin therapy as a part of such a program should be screened by means of preoperative determination of the partial thromboplastin time, to identify previously unsuspected bleeding disorders.
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