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  • Title: Region-specific generation of cholinergic neurons from fetal human neural stem cells grafted in adult rat.
    Author: Wu P, Tarasenko YI, Gu Y, Huang LY, Coggeshall RE, Yu Y.
    Journal: Nat Neurosci; 2002 Dec; 5(12):1271-8. PubMed ID: 12426573.
    Abstract:
    Pluripotent or multipotent stem cells isolated from human embryos or adult central nervous system (CNS) may provide new neurons to ameliorate neural disorders. A major obstacle, however, is that the majority of such cells do not differentiate into neurons when grafted into non-neurogenic areas of the adult CNS. Here we report a new in vitro priming procedure that generates a nearly pure population of neurons from fetal human neural stem cells (hNSCs) transplanted into adult rat CNS. Furthermore, the grafted cells differentiated by acquiring a cholinergic phenotype in a region-specific manner. This technology may advance stem cell-based therapy to replace lost neurons in neural injury or neurodegenerative disorders.
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