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  • Title: [3-(Nitrobenzylidene)-2,4(3H,5H)-furandione in the Hantzsch-pyridine synthesis 2. 6,7-Dihydrophthalide].
    Author: Görlitzer K, Bartke U.
    Journal: Pharmazie; 2002 Oct; 57(10):679-81. PubMed ID: 12426947.
    Abstract:
    Melting the 3-(o- and p-nitrobenzylidene)tetronic acids 2a and 2c with the enaminocarbonyl compounds 1 at 70-90 degrees C yields the hexahydro-7a-hydroxyfuro[3,4-b]-pyridines 3, while with the m-nitro compound 2b at 100 degrees C the 6,7-dihydrophthalides 4 are obtained. Dehydrogenation of the dihydro derivatives 4 with activated manganese dioxide affords the phthalides 5.
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