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  • Title: [Use of guthimine for treatment of intestinal paresis in peritonitis under experimental and clinical conditions].
    Author: Timofeev NN, Frolov SF, Zhitniuk RI.
    Journal: Vestn Khir Im I I Grek; 1975 Aug; 115(8):39-43. PubMed ID: 1242832.
    Abstract:
    A new stimulator of intestinal peristalsis-guthymine (guanylthiourea) was used experimentally and clinically for treatment of the bowel paresis in peritonitis. Preliminary, in experiments on 53 rabbits with colibacillar peritonitis an efficacy of guthymine was compared with other stimulators of the gastrointestinal tract: proserine, a hypertonic solution of sodium chloride and sorbitol. Guthymine was found to be the most effective drug. Clinically, in 23 of 33 patients with intestinal paresis a drip administration of 15-50 mg/Kg of guthymine would provide for aborting the signs of paresis. In 8 patients a moderately pronounced effect was noted. In 2 cases the use of guthimine failed to produce any positive effects.
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