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  • Title: Treatment with prostaglandin F2alpha increases expression of prostaglandin synthase-2 in the rat corpus luteum.
    Author: Narayansingh RM, Senchyna M, Carlson JC.
    Journal: Prostaglandins Other Lipid Mediat; 2002 Sep; 70(1-2):145-60. PubMed ID: 12428685.
    Abstract:
    Recent studies indicate that the corpus luteum (CL) may be a source of prostaglandin F2alpha (PGF2alpha) for regression. We investigated expression of mRNA and protein for prostaglandin G/H synthase (PGHS) in the CL of immature superovulated rats following administration of PGF2alpha. We observed an increase in mRNA for PGHS-2, the induced isoform, at 1 h and protein at 8 and 24 h after treatment. One hour after PGF2alpha, there was also a progressive decrease in plasma progesterone concentration. There were no changes, however, in expression of PGHS-1, the constitutive isoform, over the 24 h sampling period. These results indicate that PGHS-2 increases following PGF2alpha treatment and that expression of this enzyme in the rat CL may contribute to the luteolytic mechanism.
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