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  • Title: Severe neutropenia due to naproxen therapy in rheumatoid arthritis: a case report and review of literature.
    Author: Kalksma R, Jansen TL, Bruyn GA.
    Journal: Neth J Med; 2002 Aug; 60(7):289-91. PubMed ID: 12430576.
    Abstract:
    Rheumatoid arthritis is a chronic inflammatory disease that primarily affects the joints and is often treated with non-steroidal anti-inflammatory drugs (NSAIDs) on demand and disease-modifying antirheumatic drugs (DMARDs), with a relatively low risk of side effects. Although an infrequent side effect, neutropenia has been described as a sequel of NSAIDs. We report a case of neutropenia proven (by rechallenge) to be due to naproxen therapy. The literature on neutropenia during treatment with NSAIDs and DMARDs is briefly reviewed.
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