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  • Title: [Effects of midodrine on symptomatic hypotension during hemodialysis].
    Author: Cotera A, Alvo M, Sanhueza ME, Elgueta L, Gormaz JP, Ibáñez C, Cuadra C.
    Journal: Rev Med Chil; 2002 Sep; 130(9):1009-13. PubMed ID: 12434648.
    Abstract:
    BACKGROUND: Hypotension occurs in 20% of hemodialysis procedures. AIM: To study the effects of midodrine on hypotension during hemodialysis. PATIENTS AND METHODS: Ten patients on chronic hemodialysis and with a history of hypotension during the procedure, were studied. They received midodrine 10 mg per os or placebo during 5 dialytic procedures each, in a double blind cross over design. RESULTS: Blood pressure levels prior to dialysis were similar during the midodrine or placebo administration periods. During dialysis, systolic blood pressure fell 19.3 +/- 28 mmHg with midodrine and 23.4 +/- 28 mmHg with placebo. Diastolic blood pressure fell 7.3 +/- 11.5 mmHg with midodrine and 11.1 +/- 12 mmHg with placebo. The reduction in median arterial pressure was also less pronounced with midodrine. CONCLUSIONS: Midodrine lessens the fall in arterial pressure during hemodialysis, in patients with symptomatic hypotension.
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