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  • Title: Homocysteine promotes the LDL oxidase activity of ceruloplasmin.
    Author: Exner M, Hermann M, Hofbauer R, Hartmann B, Kapiotis S, Gmeiner B.
    Journal: FEBS Lett; 2002 Nov 20; 531(3):402-6. PubMed ID: 12435583.
    Abstract:
    Ceruloplasmin (CP) oxidises low density lipoprotein (LDL). The oxidising potential depends on the formation of Cu(+)-CP which is redox-cycled during oxidation. Homocysteine (HCY) reduces free Cu(2+), potentiating its cell-damaging property. We show that HCY enhanced LDL oxidation by CP, but did not activate the LDL oxidising potential of Cu(2+)-diamine oxidase. Selective removal of the redox-active Cu(2+) abolished the LDL oxidase activity of CP. However, HCY partially restored the LDL oxidase activity of redox-copper depleted CP, indicating that the remaining six copper atoms in CP may also be involved in the process. Spectroscopic and oxidation inhibition studies using the Cu(+)-reagent bathocuproine revealed that HCY induced Cu(+)-CP formation, thus promoting its LDL oxidase activity.
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