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  • Title: [Spontaneous and induced variability of Streptomyces aureofaciens--chlortetracycline producer].
    Author: Stryzhkova HM, Kopeĭko OP, Lavrinchuk VIa, Bambura OI, Matseliukh BP.
    Journal: Mikrobiol Z; 2002; 64(4):19-23. PubMed ID: 12436867.
    Abstract:
    Spontaneous and induced variability of Streptomyces aureofaciens strain T[symbol: see text] 633 [symbol: see text] and its variants has been investigated. Correlative relation between the antibiotic formation and colonies morphology was observed. Combined effect of nitrosoguanidine and UV-beams resulted in the obtaining of 27 variants which exceeded activity of strain T[symbol: see text] 633 [symbol: see text] by 30-35% and were stable as to antibiotic biosynthesis during 7-10 generations.
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