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  • Title: Functional consequences of cathepsin L deficiency in human lung epithelial cells.
    Author: Wille A, Heimburg A, Gerber A, Reisenauer A, Welte T, Bühling F.
    Journal: Biol Chem; 2002; 383(7-8):1291-6. PubMed ID: 12437119.
    Abstract:
    Cathepsin L is a cysteine protease of the papain family. Lung epithelial cells play an important role in host defence. The aim of the present study was to investigate the functional role of cathepsin L in the human lung carcinoma cell line A549. Cathepsin L-deficient A549 clones were generated. They showed a significant lower proliferation and secreted 5- to 8-fold more IL-8 than the control cells. The production of IL-6, IL-18, and TGF-beta1/2 was not affected significantly. It was shown that the cells upregulate IL-8 transcription and that IL-8 in the culture supernatant is necessary for the containment of cellular proliferation. In conclusion, the data show that suppression of cathepsin L expression in A549 cells leads to a growth inhibition which is partially compensated by an upregulation of IL-8 production.
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