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  • Title: Proteolytic processing of chromogranins is modified in brains of transgenic mice.
    Author: Laslop A, Becker A, Lindberg I, Fischer-Colbrie R.
    Journal: Ann N Y Acad Sci; 2002 Oct; 971():49-52. PubMed ID: 12438088.
    Abstract:
    In normal brain, secretogranin II and chromogranins A and S are extensively converted by endopeptidases to the peptides secretoneurin, GE-19, and PE-11, respectively. After genetic knockout of PC2 or its helper protein 7B2, but not after mutation of carboxypeptidase E, endoproteolytic processing decreased, as indicated by appearance of intermediate-sized processing products.
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