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  • Title: Studies on melanogenesis of tryptophan in Harding-Passey mouse melanoma.
    Author: Costa C, Allegri G, De Antoni A.
    Journal: Acta Vitaminol Enzymol; 1975; 29(1-6):223-6. PubMed ID: 1244096.
    Abstract:
    D,L-tryptophan[benzene ring-14C (U)] and D,L-tryptophan (methylene-14C) are incorporated significantly into melanin of Harding-Passey mouse melanoma. D,L-5-hydroxytryptophan (methylene-14C) and 5-hydroxytryptamine-3-14C (serotonin) gave an incorporation of radioactivity into melanin significantly lower than tryptophan. D,L-tyrosine-2-14C was incorporated into melanin as well as tryptophan. Therefore tryptophan must be considered an important precursor in the biogenesis of melanins too.
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