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  • Title: [Perspectives for diabetes treatment through pancreas transplantation or islet transplantation].
    Author: Oberholzer J, Morel P.
    Journal: Diabetes Metab; 2002 Sep; 28(4 Pt 2):2S27-2S32. PubMed ID: 12442061.
    Abstract:
    Replacement of beta-cell function by transplantation of endocrine tissue is an alternative treatment for patients with complicated type 1 diabetes. Pancreas transplantation is presently the only treatment allowing to normalise glycemia without increasing the risk of hypoglycemia and to stop exogenous insulin-therapy. In spite of postoperative morbidity and mortality, pancreas transplantation improves quality of life, reduces cardiovascular risk factors and prolongs the life expectancy of diabetic patients with end-stage kidney failure. Islet transplantation is still an experimental procedure. However, the results obtained recently are a proof of principle that a cellular transplant can induce normoglycemia and insulin-independence in diabetic patients. In this review, the results and perspectives of pancreas and islet transplantation are discussed.
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