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  • Title: [Recurrent hypertensive crises associated with severe orthostatic hypotension due to baroreflex failure syndrome].
    Author: Frantz S, Lührs H, Allolio B, Koller ML.
    Journal: Z Kardiol; 2002 Nov; 91(11):946-50. PubMed ID: 12442198.
    Abstract:
    The baroreflex mechanism is a central part of the regulation of the cardiovascular system, particularly in the control of vagal and sympathetic outflow to the heart and the peripheral circulation. Failure of the baroreflex is a rare cause of secondary hypertension. It is characterized by drastic changes in sympathetic activation and blood pressure following complete denervation of the baroreflex. Here, we report a case of baroreflex failure following bilateral carotid artery surgery and radiation. Moreover, postoperative orthostatic hypotension with recurrent syncope suggests a rare subform, the selective baroreflex failure, where efferent parasympathetic activity is preserved. Both high blood pressure and orthostatically induced syncope improved substantially after treatment with clonidine.
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