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  • Title: [Polymorphism of the angiotensin-converting enzyme gene in cardiovascular pathology].
    Author: Tseluĭko VI, Kravchenko NA, L'vova AB, Liashenko AV.
    Journal: Tsitol Genet; 2002; 36(5):30-3. PubMed ID: 12442545.
    Abstract:
    The aim of the study was to investigate influence of polymorphism of angiotensin-converting enzyme (ACE) gene on peculiarities of clinical process of such cardiovascular pathology as hypertrophic cardiomyopathy, coronary arterial disease and arterial hypertension. The polymorphism of ACE gene was studied in 98 patients: 38 with hypertrophic cardiomyopathy, 35 with coronary arterial disease and 25 with arterial hypertension. Nuclear DNA was extracted from blood leukocytes by phenol-chloroform method. Genotypes of ACE gene were determined by polymeraze chain reaction, followed with electrophoresis in agarose gel. It has been established, that I/D polymorphism of ACE gene has important modificative significance in clinical process at the mentioned diseases.
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