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  • Title: The synthesis of connective tissue protein in smooth muscle cells.
    Author: Faris B, Salcedo LL, Cook V, Johnson L, Foster JA, Franzblau C.
    Journal: Biochim Biophys Acta; 1976 Jan 05; 418(1):93-103. PubMed ID: 1244854.
    Abstract:
    The synthesis of elastin by smooth muscle cells was clearly demonstrated by amino acid analyses and the presence of lysine-derived crosslinks. The values obtained were compatible with those found in amorphous elastin isolated from rabbit aortic tissue. Collagen synthesis by these same cells was monitored by the appearance of [14C] hydroxyproline when the cells were grown in the presence of [14C] proline. When the cells were pulsed with [14C] lysine, one could detect [14C] hydroxylysine and [14C] glucosylgalactosylhydroxylysine. Further evidence for the synthesis of elastin and collagen was the finding of radiolabelled epsilon-hydroxynorleucine and the reduced aldol condensate of two residues of allysine after reduction of [14C] lysine pulsed cells with NaBH4.
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