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  • Title: Selenium status in psoriasis and its relationship with alcohol consumption.
    Author: Serwin AB, Waşowicz W, Gromadzińska J, Chodynicka B.
    Journal: Biol Trace Elem Res; 2002 Nov; 89(2):127-37. PubMed ID: 12449236.
    Abstract:
    The aim of the study was to examine the influence of alcohol consumption on the severity of psoriasis and selenium (Se) concentration and Se-dependent gluathione peroxidase activity in plasma (pl-GSH-Px) and in erythrocytes (RBC-GSH-Px) in psoriatic patients. Thirty-five in-patients with psoriasis lasting <10 mo and 42 with psoriasis lasting >3 yr constituted groups 1 and 2, respectively. The severity of psoriasis was assessed using the PASI scoring system and the consumption of alcohol, using a structured questionnaire. The Se concentration was 47.11+/-11.61 microg/L in group 1 and 38.69+/-13.22 microg/L in group 2 (p<0.05), the pl-GSH-Px was 0.15+/-0.04 U/mL and 0.14+/-0.04 U/mL (p>0.05), and the RBC-GSH-Px was 13.97+/-4.27 U/g Hb and 13.16+/-3.85 U/g Hb (p>0.05), respectively. In excessive drinkers (<10% of patients, all males), the Se concentration was 32.84+/-10.88 microg/L, the pl-GSH-Px was 0.15+/-0.03 U/mL, and the RBC-GSH-Px was 11.64+/-3.32 U/g Hb. A low RBC-GSH-Px correlated to the consumption of high-grade alcoholic beverages (R=-0.45, p<0.05) and to the PASI value (R=-0.37, p<0.05) in group 2. Depressed Se concentration and Se-dependent GSH-Px can be related to the severity and a duration of psoriasis. The excessive consumption of alcohol is associated with severity of the disease and with low activity of GSH-Px in erythrocytes in patients with long-lasting psoriasis.
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