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  • Title: Therapeutic apheresis exchange in two patients with prolidase deficiency.
    Author: Lupi A, Casado B, Soli M, Bertazzoni M, Annovazzi L, Viglio S, Cetta G, Iadarola P.
    Journal: Br J Dermatol; 2002 Dec; 147(6):1237-40. PubMed ID: 12452876.
    Abstract:
    BACKGROUND: Prolidase deficiency is a rare genetic disorder for which a cure has not yet been found. OBJECTIVES: To assess the effectiveness of apheresis exchange as a new therapeutic approach. METHODS: Apheresis exchanges were repeated monthly for four consecutive months, in parallel, on two patients, replacing prolidase-deficient red blood cells with normal filtered cells. Prolidase activity and urinary dipeptides were determined at regular intervals. RESULTS: The constant presence of active prolidase inside cells allowed a continuous, although partial, degradation of imidodipeptides, with a concomitant improvement of skin ulceration. CONCLUSIONS: Apheresis exchange could be a reasonable way of obtaining a clinical improvement in these patients.
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