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  • Title: Gastrointestinal outcomes: evidence for risk reduction in patients using coxibs.
    Author: Scheiman JM.
    Journal: Am J Manag Care; 2002 Nov; 8(17 Suppl):S518-28. PubMed ID: 12458821.
    Abstract:
    This paper examines the importance of clinically relevant gastrointestinal (GI) outcomes in patients using nonsteroidal anti-inflammatory drugs (NSAIDs) and the risk reduction for adverse GI events associated with cyclooxygenase (COX)-2-selective inhibitors. Four large outcomes trials are reviewed, 2 each with celecoxib and rofecoxib. The results of outcomes studies are consistent with randomized controlled trials and demonstrate that coxibs are associated with significant reductions in clinically relevant GI outcomes. The reductions are observed in patients without GI risk factors as well as in those at risk, suggesting that these drugs have the potential to improve outcomes for all patients requiring NSAIDs.
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