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  • Title: [Diagnosis and treatment of refractory sprue].
    Author: Garrido A, Guerrero FJ, Lepe JA, Ortega C, Muñoz E.
    Journal: Gastroenterol Hepatol; 2002 Dec; 25(10):594-6. PubMed ID: 12459121.
    Abstract:
    Celiac disease is a gluten-sensitive enteropathy characterized by villous atrophy that is reversed by gluten withdrawal. A minority of these patients is resistant to a gluten-free diet or, after a period of remission, they experience relapse despite continued adherence to treatment, which is called unclassified sprue or refractory sprue.The prognosis of refractory sprue may be poor: patients may die of severe malabsorption or from the development of an enteropathy-associated T-cell lymphoma. We report a 72-year-old-woman with a diagnosis of refractory sprue who responded well to treatment with corticosteroids and a gluten-free diet.
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