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  • Title: Hormone responsiveness of plasma membrane-bound enzymes in normal and regenerating rat liver.
    Author: Leoni S, Luly P, Mangiantini MT, Spagnuolo S, Trentalance A, Verna R.
    Journal: Biochim Biophys Acta; 1975 Jun 25; 394(2):317-22. PubMed ID: 124602.
    Abstract:
    The hormonal responsiveness of plasma membrane-bound enzymes (Na-+-K-+)-ATPase and adenylate cyclase has been investigated in normal and regenerating rat liver. (Na-+-K-+)-ATPase basal activity is not affected by surgery and only slightly affected by partial hepatectomy; its response to epinephrine and cyclic AMP is decreased only 15 h after hepatectomy. Adenylate cyclase activity of plasma membranes from untreated animals is stimulated by parathyroid hormone and thyroxine; partial hepatectomy increased basal activity as well as the stimulation exerted by the aforementioned hormones, when glucagon and epinephrine sensitivity is essentially unaltered.
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