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  • Title: Looking backwards: a possible new path for drug discovery in psychopharmacology.
    Author: Shorter E.
    Journal: Nat Rev Drug Discov; 2002 Dec; 1(12):1003-6. PubMed ID: 12461521.
    Abstract:
    The history of psychopharmacology is littered with type II errors--the rejection of effective compounds in the specious belief that they were inefficacious because they had failed to beat placebo in a controlled trial. Revisiting some of these drugs to establish their receptor profile, and then determining what patentable compounds now on the shelf match that profile, might represent a possible future pathway to drug discovery. This article looks at the special circumstances in which numerous potentially effective drugs were withdrawn in the United States.
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