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  • Title: Mycophenolate mofetil and leflunomide: promising compounds for the treatment of skin diseases.
    Author: Frieling U, Luger TA.
    Journal: Clin Exp Dermatol; 2002 Oct; 27(7):562-70. PubMed ID: 12464151.
    Abstract:
    In the past decade, there has been enormous progress in the understanding of the pathomechanisms of immune-mediated diseases, which has led to major advances in immunotherapeutic strategies. As a consequence, the armamentarium of specific and nonspecific immune-modulating and immunosuppressive drugs for the treatment of skin diseases has been widely extended. Among the nonspecific immunomodulators, mycophenolate mofetil and leflunomide show promising effects in a variety of autoimmune and inflammatory skin disorders. Both compounds inhibit a key enzyme in nucleotide biosynthesis, a step that is pivotal for the production of cytotoxic T cells and antibody formation. They do not act in the nucleus, which may explain their advantageous side-effect profile.
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