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  • Title: A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells.
    Author: Wu X, Ding S, Ding Q, Gray NS, Schultz PG.
    Journal: J Am Chem Soc; 2002 Dec 11; 124(49):14520-1. PubMed ID: 12465946.
    Abstract:
    Purmorphamine, which is a 2,6,9-trisubstituted purine compound, was discovered through cell-based high-throughput screening from a heterocycle combinatorial library. It differentiates multipotent mesenchymal progenitor cells into an osteoblast lineage. It will serve as a unique chemical tool to study the molecular mechanisms of osteogenesis of stem cells and bone development.
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