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  • Title: Stomatocyte-discocyte-echinocyte sequence of the human red blood cell: evidence for the bilayer- couple hypothesis from membrane mechanics.
    Author: Lim H W G, Wortis M, Mukhopadhyay R.
    Journal: Proc Natl Acad Sci U S A; 2002 Dec 24; 99(26):16766-9. PubMed ID: 12471152.
    Abstract:
    Red-cell shape is encoded in the mechanical properties of the membrane. The plasma membrane contributes bending rigidity; the protein-based membrane skeleton contributes stretch and shear elasticity. When both effects are included, membrane mechanics can reproduce in detail the full stomatocyte-discocyte-echinocyte sequence by variation of a single parameter related to the bilayer couple originally introduced by Sheetz and Singer [Sheetz, M. P. & Singer, S. J. (1974) Proc. Natl. Acad. Sci. USA 71, 4457-4461].
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