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  • Title: [Biochemical and immunological markers of osteoporosis in patients with chronic obstructive pulmonary disease].
    Author: Kochetkova EA, Gel'tser BI, Semisotova EF, Volkova MV.
    Journal: Klin Med (Mosk); 2002; 80(10):31-5. PubMed ID: 12471835.
    Abstract:
    A cytokine profile and changes in bone metabolism were studied in 95 patients (30 females and 65 males) with chronic obstructive pulmonary disease (COPD). Subnormal bone density was diagnosed in 78% patients with COPD. Frequency of osteoporosis discovery in emphysema was higher than in chronic obstructive bronchitis and the degree of density loss in bone tissue depended on ventilation disturbance. Intensification of bone resorption in relatively stable osteogenesis was encountered in 73.6% patients and manifested in elevated CrossLaps concentration. A close correlation exists between proinflammatory cytokines, bone density and indices of bone metabolism in COPD. This suggests a significant role of cytokine-mediated mechanisms in pathogenesis of pulmonogenic osteopenia.
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