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  • Title: Hyperuricosuric calcium nephrolithiasis.
    Author: Sorensen CM, Chandhoke PS.
    Journal: Endocrinol Metab Clin North Am; 2002 Dec; 31(4):915-25. PubMed ID: 12474638.
    Abstract:
    Since the findings of Yü and Gutman [1], the hyperuricosuric calcium stone former is a unique clinical entity. While an impressive number of clinical and epidemiologic studies implicate hyperuricosuria in calcium stone formation, the exact physicochemical mechanism by which uric acid affects calcium oxalate crystallization has not been proven. Allopurinol decreases stone recurrences and is the drug of choice for patients with isolated HCN.
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