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  • Title: [The role of mitogen-activated protein kinase (MAPK) pathway in the action mechanism of PYM-induced KB cells apoptosis].
    Author: Dai G, Zhang Z, Zhou M, Yu S.
    Journal: Zhonghua Kou Qiang Yi Xue Za Zhi; 2002 Mar; 37(2):97-8. PubMed ID: 12475417.
    Abstract:
    OBJECTIVE: To study the role of mitogen-activated protein kinase (MAPK) pathway in the action mechanism of PYM-induced KB cell apoptosis. METHODS: Western blot analysis was used to investigate the expression of the mitogen-activated protein kinase. RESULTS: When treated with PYM in cultured KB cells, the extracellular signal-regulated kinase (ERKl/2) showed a dose-and time-dependent decreasing in phosphorylation status of these proteins through a western blot analysis, whereas protein levels of p38 MAPK remained unchanged. CONCLUSIONS: The mitogen-activated protein kinase (MAPK) pathway may play an important ro1e in PYM-induced apoptosis of KB cells.
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