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  • Title: [Up-expression of IL-6 and down-expression of TNFalpha may be involved in the regulation of apoptosis induced by antisense bcl-2 oligodeoxynucleotides].
    Author: Chen X, Hu J, Chen Z, Lu L.
    Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi; 2002 Dec; 19(6):495-8. PubMed ID: 12476423.
    Abstract:
    OBJECTIVE: To investigate the regulation mechanism of apoptosis induced by the antisense bcl-2 treatment. METHODS: DNA content analysis and terminal-deoxynucleotidyl transferase mediated nick end labeling (TUNEL) were adopted to detect apoptosis. Semi-quantitative reverse transcription-PCR was performed to detect the mRNA expression of bcl-2 c-myc survivin bax s100A(2) TNFalpha TGFbeta(1) and IL-6 in the small-cell lung cancer cell line NCI-H446 treated with antisense bcl-2 oligodeoxynucliotide. RESULTS: bcl-2 AS-PS-ODN treatment could induce apoptosis, accompanied with 72.71% up-regulation of IL-6 and 65.90% down-regulation of TNFalpha, whereas little or no effect was seen on c-myc survivin bax s100A(2) and TGFbeta(1). CONCLUSION: IL-6 and TNFalpha may be involved in the regulation of apoptosis induced by antisense bcl-2 treatment.
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