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  • Title: Primary undifferentiated small cell carcinoma (Merkel cell carcinoma) in a patient after heart transplantation--case report.
    Author: Maksymiuk B, Wygoda A, Zakliczyński M, Paleń P.
    Journal: Pol J Pathol; 2002; 53(3):177-80. PubMed ID: 12476622.
    Abstract:
    Here we report a case of a 48-year-old man after heart transplantation in whom two years after the procedure an appendage germ tumour was diagnosed and a year after its removal in the same area a primary undifferentiated small cell carcinoma (Merkel cell carcinoma) with metastases to the axillary lymph nodes was detected. The diagnosis of Merkel cell carcinoma was confirmed by immunohistochemical staining showing a typical perinuclear expression of cytokeratin 20 with the absence of reactivity with wide spectrum cytokeratin and the presence of neuroendocrine markers of neurone-specific enolase and chromogranin. Primary undifferentiated small cell carcinoma occurs more frequently in patients receiving immunosuppressive treatment as compared with a general population and occurs much more frequently in those below 50 years of age.
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