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  • Title: [Clinical study on single-dose rhG-CSF combined with chemotherapy in autologous peripheral blood stem cell transplantation].
    Author: Tian H, Zhou SY.
    Journal: Ai Zheng; 2002 Aug; 21(8):896-9. PubMed ID: 12478902.
    Abstract:
    BACKGROUND & OBJECTIVE: This study was designed to evaluate the effectiveness of high-dose chemotherapy plus single daily dose of 250 micrograms/d rhG-CSF(lenograstim) in autologous peripheral blood stem cells mobilization and hematopoietic reconstitution after transplantation. METHODS: The study included a group of 55 consecutive patients with hematological malignancies (28 cases of acute myelogenous leukemia, 9 cases of acute lymphoblastic leukemia, 14 cases of non-Hodgkin's lymphoma, 4 cases of other disease) from October 1999 to December 2001 undergoing either EA or other intensive chemotherapies as CTX, G-CSF mobilization began from the day when the WBC count reached nadir until the day of apheresis, then after stem cell reinfusion G-CSF support was given on day +3 until neutrophil recovery. The dose of G-CSF both in mobilization and recovery support was 250 micrograms/d s.c. despite the body weight of patients. RESULTS: The average time of G-CSF administrating as a mobilizing reagent was 7.12 days(range 3-14 days), and the mean time of interval from the beginning of chemotherapy to apheresis was 18.08 +/- 3.63 days. All patients need an average of 1.3 times for apheresis. The median mononuclear cell and CD34+ cell yield were 4.09 x 10(8)/kg and 8.5 x 10(6)/kg, respectively. G-CSF was used after transplantation for a median time of 8 days(range 4-19). All patients achieved an ANC > 0.5 x 10(9)/L after a median of 10.5 days (range 8-26). No severe toxic reaction was observed. CONCLUSION: We concluded that chemotherapy plus rhG-CSF(lenograstim) given in the single dose fashion can be used in both mobilizing and post transplantation setting with satisfying outcome.
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