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  • Title: A diffusion tensor MRI study of basal ganglia from patients with ADEM.
    Author: Holtmannspötter M, Inglese M, Rovaris M, Rocca MA, Codella M, Filippi M.
    Journal: J Neurol Sci; 2003 Jan 15; 206(1):27-30. PubMed ID: 12480081.
    Abstract:
    Using diffusion tensor (DT) MRI and histogram analysis, we measured mean diffusivity ((-)D) of basal ganglia grey matter (GM) from eight patients with acute disseminated encephalomyelitis (ADEM), 10 patients with multiple sclerosis (MS), and 10 healthy controls. Patients with ADEM had higher average (-)D (p=0.02) and lower (-)D histogram peak height (p=0.008) of the basal ganglia GM than patients with MS. Microscopic tissue damage occurs in the basal ganglia of ADEM patients, but not in MS patients with a similar burden of MRI-visible brain lesions.
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