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  • Title: Neuroprotective effects of YM872 coadministered with t-PA in a rat embolic stroke model.
    Author: Suzuki M, Sasamata M, Miyata K.
    Journal: Brain Res; 2003 Jan 03; 959(1):169-72. PubMed ID: 12480171.
    Abstract:
    YM872, an AMPA receptor antagonist, was administered together with t-PA to investigate the effects of coadministration on neuroprotection in a rat embolic stroke model, when administered 2 h after embolism. T-PA or YM872 alone decreased infarct volume and improved the neurological deficit score. Coadministration of YM872 and t-PA resulted in a further decrease in infarct volume and improvement of the neurological score as compared with single administration of t-PA. These data demonstrate that coadministration of YM872 and t-PA produces more potent neuroprotective effects than when t-PA is administered alone.
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