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  • Title: Synthesis of 2-substituted-pyrrolidinethiourea derivatives and their antagonist effect on vanilloid receptor.
    Author: Park Hg, Park Mk, Choi Jy, Choi Sh, Lee J, Suh Yg, Oh U, Lee J, Kim HD, Park YH, Jeong YS, Choi JK, Jew Ss.
    Journal: Bioorg Med Chem Lett; 2003 Jan 20; 13(2):197-200. PubMed ID: 12482422.
    Abstract:
    Four pyrrolidine derivatives were prepared by the formation of a 5-membered ring based on capsazepine. Among them, the two carbon extended derivatives, 4a (IC(50)=55 microM) and 4b (IC(50)=3 microM), both showed different levels of antagonist activity against the vanilloid receptor in a (45)Ca(2+)-influx assay.
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