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  • Title: Centrofacial malignant T-cell lymphoma exhibiting recurrent fever and skin ulcer in a 3-year-old girl.
    Author: Kakihara T, Imai C, Hotta H, Ikarashi Y, Tanaka A, Uchiyama M.
    Journal: Pediatr Hematol Oncol; 2002 Dec; 19(8):575-80. PubMed ID: 12487833.
    Abstract:
    A rare case of undetermined fever and skin ulcers is reported. The patient had an 8-month history of recurrent fever, destructive ulceration of the midline facial tissue, and symmetrical skin ulcer in the cheeks and the back of the hand. Pathological examination revealed that the patient had lethal midline granuloma (centrofacial malignant T-cell lymphoma), which is very rare in childhood. Centrofacial malignant T-cell lymphoma should be considered as a differential diagnosis of unexplained fever and skin ulcer in children.
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