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  • Title: Bilateral exopthalmus due to retro-orbital chloromas in a boy with t(8;21)- positive acute myeloblastic acute leukemia.
    Author: Bönig H, Göbel U, Nürnberger W.
    Journal: Pediatr Hematol Oncol; 2002 Dec; 19(8):597-600. PubMed ID: 12487837.
    Abstract:
    Exophthalmus is an infrequent finding in pediatrics. The differential diagnoses include chloromas, tumors of immature hematopoietic precursor cells. The case of a child with acute myeloid leukemia is reported. The presenting signs had included exophthalmus and nasal speech due to retro-orbital and sinusoidal chloromas, respectively. As in most cases of pediatric acute myeloid leukemia with chloroma, the AML1/ETO fusion gene was found, which portended a not unfavorable prognosis. This child was treated according to the AML-BFM 98 protocol and achieved an ongoing remission. The exophthalmus resolved completely.
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