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  • Title: Results of interval debulking surgery in advanced stage ovarian cancer: an exposed-non-exposed study.
    Author: Morice P, Brehier-Ollive D, Rey A, Atallah D, Lhommé C, Pautier P, Pomel C, Camatte S, Duvillard P, Castaigne D.
    Journal: Ann Oncol; 2003 Jan; 14(1):74-7. PubMed ID: 12488296.
    Abstract:
    BACKGROUND: To study the results of interval debulking surgery (IDS) in patients treated for 'unresectable' advanced stage ovarian cancer compared with primary debulking surgery (PDS) followed by chemotherapy. PATIENTS AND METHODS: An exposed-non-exposed study including a group of 34 patients who underwent an IDS and were matched to an historic control group of 34 patients treated with PDS. RESULTS: Optimal cytoreductive surgery was achieved in 94% (32 out of 34) of patients in both groups. The rates of post-operative morbidity, blood transfusion and median length of hospitalisation were significantly reduced in the study (IDS) group, but survival did not differ in both groups. CONCLUSIONS: IDS in patients with advanced stage ovarian cancer offers the same chance of survival as PDS, but it is better tolerated.
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