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  • Title: Understanding the roles of the transcription factors nuclear factor-kappaB and hypoxia-inducible factor-1alpha in lung injury.
    Author: Craig K, Dorscheid D.
    Journal: Crit Care; 2002 Dec; 6(6):471-2. PubMed ID: 12493066.
    Abstract:
    The role of oxidative stress in regulating transcription factors and specific gene responses in critical illness is a new and emerging area. A better understanding of the proinflammatory oxidant stimuli of reactive oxygen species generation and how this generates the clinical phenotype of acute lung injury by regulating gene expression may allow the development of new therapeutic strategies. In his review John Haddad describes the present data and role for transcription factors nuclear factor-κB and hypoxia-inducible factor-1α in acute lung injury.
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