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  • Title: Cutting edge: identification of the targets of clonal deletion in an unmanipulated thymus.
    Author: Cho HJ, Edmondson SG, Miller AD, Sellars M, Alexander ST, Somersan S, Punt JA.
    Journal: J Immunol; 2003 Jan 01; 170(1):10-3. PubMed ID: 12496375.
    Abstract:
    Autoreactive thymocytes can be eliminated by clonal deletion during their development in the thymus. The precise developmental stage(s) at which clonal deletion occurs in a normal thymus has been difficult to assess, in large part because of the absence of a specific marker for TCR-mediated apoptosis. In this report, we reveal that Nur77 expression can be used as a specific marker of clonal deletion in an unmanipulated thymus and directly identify TCRintCD4+CD8+ and semimature CD4+CD8- thymocytes as the principal targets of deletion. These data indicate that clonal deletion normally occurs at a relatively late stage of development, as cells mature from CD4+CD8+ thymocytes to single-positive T cells.
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