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  • Title: Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop.
    Author: Seidel-Rogol BL, McCulloch V, Shadel GS.
    Journal: Nat Genet; 2003 Jan; 33(1):23-4. PubMed ID: 12496758.
    Abstract:
    Human mitochondrial transcription factor B1 (h-mtTFB1) has an unprecedented relationship to RNA methyltransferases. Here, we show that this protein methylates a conserved stem-loop in bacterial 16S rRNA and that the homologous sequence in the human mitochondrial 12S molecule is similarly modified. Thus, h-mtTFB1 appears to be dual-function protein, acting both as a transcription factor and an rRNA-modification enzyme.
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