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  • Title: Antifertility agents. 12. Structure-activity relationship of 3,4-diphenylchromenes and -chromans.
    Author: Ray S, Grover PK, Kamboj VP, Setty BS, Kar AB, Anand N.
    Journal: J Med Chem; 1976 Feb; 19(2):276-9. PubMed ID: 1249807.
    Abstract:
    Synthesis and antiimplantation activity of variously substituted 2,2-dialkyl-3,4-diphenylchromenes and 3,4-cis- and trans-chromans derived from them are described. Pregnancy-inhibiting activity in rats was exhibited by a number of these compounds, which was particularly marked in the case of 3,4-trans-3-phenyl-4-p-(beta-pyrrolidinoethoxy)-phenyl-7-methoxychroman (32), the corresponding 2,2-dimethyl analog 34, and 3-phenyl-4-p-(beta-pyrrolidinoethoxy)phenyl-7-methoxychromene (26). The structure-activity relationship of these compounds is discussed.
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