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  • Title: Preparation of antipyretic analgesic by direct compression and its evaluation.
    Author: Terashita K, Imamura K.
    Journal: Chem Pharm Bull (Tokyo); 2002 Dec; 50(12):1542-9. PubMed ID: 12499587.
    Abstract:
    Direct compression is able to produce tablets at a lower cost than wet granulation and tableting method, due to a fewer items of process validation. In this study, acetaminophen was used as a medicine with various granular diameters to formulate tablets by direct compression, thus evaluating their physical properties. Consequently, direct compression was found effective in formulating tablets with excellent physical properties, with the granular diameter taken into account. It was confirmed that tablets produced by direct compression were similar in physical properties in tablets produced by wet granulation and tableting method. Further, it was suggested that use of a dry-type binder would make it possible to provide a tablet having higher content of the medicine with excellent physical properties.
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