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  • Title: Scabrolides A-D, four new norditerpenoids isolated from the soft coral Sinularia scabra.
    Author: Sheu JH, Ahmed AF, Shiue RT, Dai CF, Kuo YH.
    Journal: J Nat Prod; 2002 Dec; 65(12):1904-8. PubMed ID: 12502336.
    Abstract:
    Four new norditerpenoids, scabrolides A-D (1-4), along with four known ones, 5-8, have been isolated from the dichloromethane extract of the Taiwanese soft coral Sinularia scabra. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analyses, while the relative configurations were determined by the NOESY experiments. The epimeric metabolites 6 and 7 have been shown to exhibit strong cytotoxic activity against KB and Hepa59T/VGH cancer cell lines.
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