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  • Title: [Research on breast cancer susceptibility genes].
    Author: Ye J, Shan BE.
    Journal: Ai Zheng; 2002 Sep; 21(9):1035-9. PubMed ID: 12508556.
    Abstract:
    With the increasing of the incidence rate of breast carcinoma year after year, the susceptibility genes of breast carcinoma was paid more and more attention. The study on susceptibility genes play an important role in early diagnosis and prevention for the individuals with family history of breast carcinoma, elucidation of pathologic mechanism of sporadic breast carcinoma, early diagnosis and adjudging prognosis, research on drug sensitivity, differential diagnosis of benign and malignant disease, etc. There were many studies on the high-penetrance susceptibility genes (BRCA1, BRCA2). However, some low-penetrance susceptibility gene, for example, the members of hormone metabolism related enzymes genes CYP family (CYP17, CYP19, CYP1A1, etc.), the carcinogen metabolism related gene (GSTM1, NAT1, NAT2), and DNA damage repair gene (ATM) were not clearly understood. The aim of this study was to review the present research situation of common susceptibility genes of breast carcinoma found already.
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