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  • Title: Meningioma presenting with Cushing's syndrome: an unusual clinical presentation.
    Author: Pecori Giraldi F, Terreni MR, Andreotti C, Losa M, Lanzi R, Pontiroli AE, Cavagnini F.
    Journal: Ann Neurol; 2003 Jan; 53(1):138-42. PubMed ID: 12509860.
    Abstract:
    We report a patient with a meningioma presenting with Cushing's syndrome, an unprecedented paraneoplastic presentation. Molecular studies, bioassay, and high-performance liquid chromatography of tumor specimens demonstrated the synthesis and secretion of bioactive corticotropin-releasing hormone. To our knowledge, this appears to be the first report of a hormone-secreting meningioma and, further, the first clearly proven case of Cushing's syndrome due to ectopic corticotropin-releasing hormone secretion without concomitant corticotropin production.
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