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  • Title: Wewakazole, a novel cyclic dodecapeptide from a Papua New Guinea Lyngbya majuscula.
    Author: Nogle LM, Marquez BL, Gerwick WH.
    Journal: Org Lett; 2003 Jan 09; 5(1):3-6. PubMed ID: 12509876.
    Abstract:
    Phytochemical examination of a Papua New Guinea collection of Lyngbya majuscula resulted in the discovery of wewakazole (1), a novel cyclic dodecapeptide containing an unprecedented six five-membered heterocycles. Multiple NMR experiments and MS/MS data were required to assemble its planar structure because of its extensively signal-overlapped NMR spectra. In particular, a 1D HMBC was utilized to orient a three amino acid fragment that could not be placed by standard spectroscopic methods. [structure--see text]
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