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  • Title: Effect of adrenaline on the glucose uptake by the canine hindlimb.
    Author: Ekhelar AI, Alada AR, Oyebola OD.
    Journal: Afr J Med Med Sci; 2002 Mar; 31(1):1-4. PubMed ID: 12518920.
    Abstract:
    The effect of adrenaline on the glucose uptake by a non-exercising hindlimb was studied in fasted anaesthetized dog. Glucose uptake (mg/min) was calculated as the product of the venous blood flow and anterio-venous glucose difference (A - V). Although, adrenaline caused significant increase in venous blood flow, it however, reduced significantly the (A - V) glucose level and the glucose uptake by the hindlimb. The adrenaline effects were however, abolished by pretreating the animal with propranolol, a beta-adrenergic blocker. It was therefore concluded that the skeletal muscle of the canine hindlimb is not involved in glucose homeostasis during adrenaline hyperglycemia.
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